Incidence and presentation of new-onset type 1 diabetes in children and adolescents from Germany during the COVID-19 pandemic 2020 and 2021: Current data from the DPV Registry.

AIMS: To determine whether the incidence of type 1 diabetes mellitus (T1D), autoantibody-negative diabetes, and diabetic ketoacidosis (DKA) at diabetes onset in 2020 and 2021 changed when compared to long-standing trends. METHODS: Our study is based on diabetes manifestation data of the 0.5-<18-year-old children/adolescents from the German multicenter Diabetes Prospective Follow-up Registry. Based on long-term pre-pandemic trends from 2011 to 2019, we estimated adjusted incidence rate ratios (IRR) for T1D and DKA, and prevalence rate ratios (PRR) regarding autoantibody status with 95 % confidence intervals (CI) for the years 2020 and 2021 (observed versus predicted rates), using multivariable negative binomial or beta-binomial regression, respectively. RESULTS: We analyzed data of 30,840 children and adolescents with new-onset T1D. The observed incidences were significantly higher than the predicted incidences (IRR2020 1.13 [1.08-1.19]; IRR2021 1.20 [1.15-1.26]). The prevalence of autoantibody-negative diabetes did not change (PRR2020 0.91 [0.75-1.10]; PRR2021 1.03 [0.86-1.24]). The incidence of DKA during the pandemic was higher than predicted (IRR2020 1.34 [1.23-1.46]; IRR2021 1.37 [1.26-1.49]). CONCLUSIONS: An increase in the incidences of T1D and DKA, but not of autoantibody-negative diabetes was observed during both pandemic years. Further monitoring and efforts for DKA prevention at onset are necessary.

Practical recommendations of the German Diabetes Society for the management of diabetes in patients with COVID-19

In subjects with an infection with the novel corona virus SARS-CoV-2 and COVID-19 disease, diabetes mellitus and cardiovascular diseases are highly prevalent comorbidities. Diabetes patients with comorbidities and/or diabetes complications seem to have a higher risk for a severe course of the COVID-19 disease including the development of ARDS or multiorgan failure. The exact interrelations between diabetes and the individual clinical course of COVID-19 are not completely understood at this time. The German Diabetes Association (DDG) summarizes basic principle practice recommendations for the treatment of patients with diabetes and concomitant COVID-19 disease. © 2021, Springer Medizin Verlag GmbH, ein Teil von Springer Nature.

Practical Recommendations for diabetes management in patients with COVID-19 disease. [German]

In subjects with an infection with the novel corona virus SARS-CoV-2 and COVID-19 disease, diabetes mellitus and cardiovascular diseases are highly prevalent comorbidities. Diabetes patients with comorbidities and/or diabetes complications seem to have a higher risk for a severe course of the COVID-19 disease including the development of ARDS or multiorgan failure. The exact interrelations between diabetes and the individual clinical course of COVID-19 are not completely understood at this time. The German Diabetes Association (DDG) summarizes basic principle practice recommendations for the treatment of patients with diabetes and concomitant COVID-19 disease. Copyright © 2020 Georg Thieme Verlag KG, Stuttgart New York.